… /FGFR signaling influences pancreatic cancer stemness by regulating SOX2. We describe
a FGFR/AKT/SOX2 signaling axis in regulating pancreatic cancer stemness by modulating the …

… FIGURE 2 | Genetic silencing of FGFR expression leads to reduced stemness in vitro and
tumor … by western blot in several pancreatic cancer cell lines. (E) Tumor formation rate 3 weeks …

… localization, thus enhancing pancreatic cancer stemness [39]… -SOX2 signaling axis was
elevated in pancreatic cancer cells … or SOX2 sensitized pancreatic cancer cells to gemcitabine …

… signaling pathway as a novel driver of OC stemness. We also provide evidence that targeting
this pathway can … seems to suppress stemness-related traits in pancreatic carcinoma [13], …

… , but it is clear that the FGFR signalling pathway is not acting in isolation. Here we describe
… the ability of pancreatic cancer cells to form spheroids, a characteristic of cancer stem cells, …

… -SOX2 axis 8 , and it controls the stemness of pancreatic cancer cells through FGFR/AKT/SOX2, …
focused on the role of SOX2 in tumor stemness and a novel signaling axis, especially in …

… the overexpressed FGFR/Akt/SOX2 signaling axis and effectively suppresses cancer-related …
contributes to the maintenance of stemness in pancreatic cancer [47]. The SOX2 expression …

… a downregulation of p38 signaling pathway with decreased … stemness by increasing stability
and nuclear localization of SOX2 in pancreatic cancer [28], promoted the reversion of tumor …

… As GSK3β may play a pleiotropic role in tumor cell proliferation and stemness [34, 49], …
carcinoma [13, 15, 16, 50, 53, 54], we aimed to identify and characterize cellular signaling pathway…

… The RAS-RAF-MEK-ERK/MAPK signaling pathway, which relates to the FGFR1 downstream
pathway, contains critical components such as mitogen-activated extracellular signal-…