[HTML][HTML] Experimental models of inflammatory bowel diseases

P Kiesler, IJ Fuss, W Strober - Cellular and molecular gastroenterology and …, 2015 - Elsevier
… Several studies were therefore conducted to define the role of IL-23 in experimental colitis
and to determine whether IL-12 or IL-23 drives the dominant effector response in these models…

Experimental models of inflammatory bowel disease

CO Elson, RB Sartor, GS Tennyson, RH Riddell - Gastroenterology, 1995 - Elsevier
effect of sulfasalazine, corticosteroids, and the experimental … of the inflammatory mediator
profile to IBD suggest that the … Histochemical study of colonic cancer in experimental colitis

Experimental colitis models: insights into the pathogenesis of inflammatory bowel disease and translational issues

V Valatas, G Bamias, G Kolios - European journal of pharmacology, 2015 - Elsevier
… Therefore, data from experimental colitis studies, showing that aberrant adaptive T cell
responses of Th1/Th17 or Th2 type generated CD-like or UC-like phenotypes respectively, are …

[HTML][HTML] Insights from advances in research of chemically induced experimental models of human inflammatory bowel disease

M Kawada, A Arihiro, E Mizoguchi - World journal of …, 2007 - ncbi.nlm.nih.gov
… To investigate the etiology of IBD, animal models of experimental colitis have been developed
and are frequently … , depending on the method used to induce the experimental colitis. …

Therapeutic effects of interleukin-4 gene transfer in experimental inflammatory bowel disease.

CM Hogaboam, BA Vallance, A Kumar… - … clinical investigation, 1997 - Am Soc Clin Investig
… The present study demonstrates that increased in vivo IL-4 levels through Ad5 gene delivery
had a marked therapeutic effect in an acute model of experimental colitis. Every parameter …

The value of experimental models of colitis in predicting efficacy of biological therapies for inflammatory bowel diseases

V Valatas, M Vakas, G Kolios - American Journal of …, 2013 - journals.physiology.org
… This review compares the results of the phase II and III trials of biologics in IBD with data
obtained from experimental colitis studies in an effort to identify factors that could optimize …

[HTML][HTML] Animal models of inflammatory bowel disease: novel experiments for revealing pathogenesis of colitis, fibrosis, and colitis-associated colon cancer

CH Lee, SJ Koh, ZA Radi, A Habtezion - Intestinal research, 2023 - synapse.koreamed.org
studies took a long time to generate colon tumors, rendering this model difficult to utilize in
experimental colitis … , peroxynitrite experimentally causes transmural inflammation and fibrosis…

Interferon-gamma is causatively involved in experimental inflammatory bowel disease in mice

R Ito, M Shin-Ya, T Kishida, A Urano… - … & Experimental …, 2006 - academic.oup.com
… Our present study focused on the acute phase of experimental colitis, in which the infiltrates
in the inflammatory colon predominantly consist of neutrophils and macrophages [35]. The …

Is nitric oxide and heparin treatment justified in inflammatory bowel disease? An experimental study

M Dobosz, L Mionskowska, S Dobrowolski… - … investigation, 1996 - Taylor & Francis
bowel disease. The aim of the study was to investigate the alterations of rectal blood
perfusion in experimental colitis with reference to nitric oxide and heparin treatment. The …

Oxidative stress and redox signaling mechanisms of inflammatory bowel disease: updated experimental and clinical evidence

H Zhu, YR Li - Experimental Biology and Medicine, 2012 - journals.sagepub.com
… mechanisms of IBD in both experimental models and clinical studies, and … gut inflammation
and oxidative stress in experimental IBD. Indeed, MPO activity in the inflamed intestinal