An RGD motif present in cadherin 17 induces integrin activation and tumor growth
RA Bartolomé, A Peláez-García, I Gomez… - Journal of Biological …, 2014 - ASBMB
Little is known about the mechanism of integrin activation by cadherin 17 (CDH17). Here we
observed the presence of a tri-peptide motif, RGD, in domain 6 of the human CDH17
sequence and other cadherins such as cadherin 5 and cadherin 6. The use of CDH17 RAD
mutants demonstrated a considerable decrease of proliferation and adhesion in RKO and
KM12SM colon cancer cells. Furthermore, RGD peptides inhibited the adhesion of both cell
lines to recombinant CDH17 domain 6. The RGD motif added exogenously to the cells …
observed the presence of a tri-peptide motif, RGD, in domain 6 of the human CDH17
sequence and other cadherins such as cadherin 5 and cadherin 6. The use of CDH17 RAD
mutants demonstrated a considerable decrease of proliferation and adhesion in RKO and
KM12SM colon cancer cells. Furthermore, RGD peptides inhibited the adhesion of both cell
lines to recombinant CDH17 domain 6. The RGD motif added exogenously to the cells …
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