An age-structured model of hepatitis B viral infection highlights the potential of different therapeutic strategies
F Fatehi, RJ Bingham, PG Stockley, R Twarock - Scientific Reports, 2022 - nature.com
Hepatitis B virus (HBV) is a global health threat, and its elimination by 2030 has been
prioritised by the World Health Organisation. Here we present an age-structured model for
the immune response to an HBV infection, which takes into account contributions from both
cell-mediated and humoral immunity. The model has been validated using published patient
data recorded during acute infection. It has been adapted to the scenarios of chronic
infection, clearance of infection, and flare-ups via variation of the immune response …
prioritised by the World Health Organisation. Here we present an age-structured model for
the immune response to an HBV infection, which takes into account contributions from both
cell-mediated and humoral immunity. The model has been validated using published patient
data recorded during acute infection. It has been adapted to the scenarios of chronic
infection, clearance of infection, and flare-ups via variation of the immune response …
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