Nucleosome turnover concomitant with incorporation of the replication-independent histone
variant H3. 3 is a hallmark of regulatory regions in the animal genome. Nucleosome turnover
is known to be universally linked to DNA accessibility and histone acetylation. In mouse
embryonic stem cells, H3. 3 is also highly enriched at interstitial heterochromatin, most
prominently at intracisternal A-particle endogenous retroviral elements. Interstitial
heterochromatin is established over confined domains by the TRIM28-KAP1/SETDB1 …

Nucleosome turnover concomitant with incorporation of the replication-independent histone
variant H3. 3 is a hallmark of regulatory regions in the animal genome. In our current
understanding, nucleosome turnover is universally linked to DNA accessibility and histone
acetylation. In mouse embryonic stem cells, H3. 3 is also highly enriched at interstitial
heterochromatin, most prominently intracisternal-A particle endogenous retroviral elements.
Interstitial heterochromatin is established over confined domains by the TRIM28/SETDB1 …