An Enantioselective Approach to Functionalized Amino Acids: Total Synthesis of Antiepileptic Drug (R)-Lacosamide
A short and highly efficient synthetic approach to enantiopure functionalized amino acids
(FAAs) 1 skeleton from racemic butadiene monoepoxide as a starting material and its
application to the total synthesis of an antiepileptic drug (R)-lacosamide 2 are described.
The synthesis utilizes the palladium catalyzed Trost's Dynamic Kinetic Asymmetric
Transformation (DYKAT) as key step.
(FAAs) 1 skeleton from racemic butadiene monoepoxide as a starting material and its
application to the total synthesis of an antiepileptic drug (R)-lacosamide 2 are described.
The synthesis utilizes the palladium catalyzed Trost's Dynamic Kinetic Asymmetric
Transformation (DYKAT) as key step.
[引用][C] An Enantioselective Approach to Functionalized Amino Acids: Total Synthesis of Antiepileptic Drug (R)-Lacosamide
G Yuvraj, PS Kumar - 2015
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