An integrated genetic-epigenetic analysis of schizophrenia: evidence for co-localization of genetic associations and differential DNA methylation
Background Schizophrenia is a highly heritable, neuropsychiatric disorder characterized by
episodic psychosis and altered cognitive function. Despite success in identifying genetic
variants associated with schizophrenia, there remains uncertainty about the causal genes
involved in disease pathogenesis and how their function is regulated. Results We performed
a multi-stage epigenome-wide association study, quantifying genome-wide patterns of DNA
methylation in a total of 1714 individuals from three independent sample cohorts. We have …
episodic psychosis and altered cognitive function. Despite success in identifying genetic
variants associated with schizophrenia, there remains uncertainty about the causal genes
involved in disease pathogenesis and how their function is regulated. Results We performed
a multi-stage epigenome-wide association study, quantifying genome-wide patterns of DNA
methylation in a total of 1714 individuals from three independent sample cohorts. We have …
An integrated genetic-epigenetic analysis of schizophrenia: Evidence for Co-localization of genetic associations and differential DNA methylation from a Large meta …
Background Schizophrenia is a severe, highly heritable, neuropsychiatric disorder
characterized by episodic psychosis and altered cognitive function. Despite recent
successes in identifying genetic variants robustly associated with susceptibility, there
remains uncertainty about the causal genes involved in disease pathogenesis and how their
function is regulated. There is growing interest in the role of developmentally regulated
epigenetic variation in the molecular etiology of schizophrenia, with studies of disease …
characterized by episodic psychosis and altered cognitive function. Despite recent
successes in identifying genetic variants robustly associated with susceptibility, there
remains uncertainty about the causal genes involved in disease pathogenesis and how their
function is regulated. There is growing interest in the role of developmentally regulated
epigenetic variation in the molecular etiology of schizophrenia, with studies of disease …
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