[PDF][PDF] An overview on fast dissolving drug delivery system

BC Nandy, B Mazumder, K Pathak… - Asian Journal of …, 2011 - academia.edu
BC Nandy, B Mazumder, K Pathak, N Saxena, S Jain, S Sharma, R Amishaben…
Asian Journal of pharmaceutical sciences and research, 2011academia.edu
Swallowing a tablet is a major difficulty encountered in case of geriatric and pediatric patient
which leads to poor patient compliance due to unpalatable taste of drug. To troubleshoot
these problems a new dosage form known as fast-dissolving tablet, has been developed
which rapidly disintegrate and dissolve in saliva. Now a number of fast-dissolving
formulations are in market like Claritin Reditab (Manufacturer RP Scherr, Inc.), Risperdal M-
Tab (Manufacturer Janseen pharmaceutics.), Tempra Quicklets (Manufacturer Cima Labs …
Abstract
Swallowing a tablet is a major difficulty encountered in case of geriatric and pediatric patient which leads to poor patient compliance due to unpalatable taste of drug. To troubleshoot these problems a new dosage form known as fast-dissolving tablet, has been developed which rapidly disintegrate and dissolve in saliva. Now a number of fast-dissolving formulations are in market like Claritin Reditab (Manufacturer RP Scherr, Inc.), Risperdal M-Tab (Manufacturer Janseen pharmaceutics.), Tempra Quicklets (Manufacturer Cima Labs, inc) and the technology is still improving. The conventional tablet seems to be most popular because of its ease of transportability and comparatively low manufacturing cost but poor patient compliance in case of pediatrics and geriatrics patients who experienced difficulties in swallowing, in response to this mouth dissolving drugs delivery system (MDDs) were developed as an alternative to tablet, cap & syrups. A variety of MDDs like mouth dissolving tablets and mouth dissolving film (MDFs) were commercialized. MDFs evolved over the past few years from by the confection and oral care market in the form of breath strips & became a novel & widely accepted form by consumers. The aim of the present review was to study the feasibility of fast dissolving drug delivery systems. Upon introduction into the mouth, these tablets dissolve or disintegrate in the mouth in the absence of additional water for easy administration of active pharmaceutical ingredients. Fast disintegrating tablets (FDTs) have received everincreasing demand during the last decade and the field has become a rapidly growing area in the pharmaceutical industry because of such tablets readily dissolve or disintegrate in the saliva generally less than 60 seconds.
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