[PDF][PDF] Analgesic and antipyretic activities of Dalbergia sissoo leaves
Indian journal of pharmacology, 2000•researchgate.net
Objective: To evaluate the analgesic and antipyretic activities of alcoholic extract of
Dalbergia sissoo leaves. Methods: The peripheral analgesic activity of Dalbergia sissoo
leaves (SLE; 100, 300 and 1000 mg/kg) was studied using acetic acid-induced writhing in
mice and by Randall-Selitto assay. The central analgesic activity of SLE was studied using
hot-plate method and tail-clip test in mice. The antipyretic activity of SLE was studied in
Brewer's yeast-induced pyrexia in rats. Results: SLE significantly decreased the writhing …
Dalbergia sissoo leaves. Methods: The peripheral analgesic activity of Dalbergia sissoo
leaves (SLE; 100, 300 and 1000 mg/kg) was studied using acetic acid-induced writhing in
mice and by Randall-Selitto assay. The central analgesic activity of SLE was studied using
hot-plate method and tail-clip test in mice. The antipyretic activity of SLE was studied in
Brewer's yeast-induced pyrexia in rats. Results: SLE significantly decreased the writhing …
Objective: To evaluate the analgesic and antipyretic activities of alcoholic extract of Dalbergia sissoo leaves.
Methods: The peripheral analgesic activity of Dalbergia sissoo leaves (SLE; 100, 300 and 1000 mg/kg) was studied using acetic acid-induced writhing in mice and by Randall-Selitto assay. The central analgesic activity of SLE was studied using hot-plate method and tail-clip test in mice. The antipyretic activity of SLE was studied in Brewer’s yeast-induced pyrexia in rats.
Results: SLE significantly decreased the writhing movements in mice in acetic acid-induced writhing test. SLE (1000 mg/kg) significantly increased the pain threshold capacity in rats in Randall-Selitto assay and the reaction time in hot-plate test but not in tail-clip test. It also showed significant antipyretic activity in Brewer’s yeast-induced pyrexia in rats throughout the observation period of 6 h.
Conclusion: SLE may have analgesic and antipyretic activities.
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