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Analysis of fexofenadine in pharmaceutical formulations using tris (1, 10‐phenanthroline)–ruthenium (II) peroxydisulphate chemiluminescence system in a multichip …

HAJ Al Lawati, ZM Al Dahmani, FEO Suliman… - …, 2011 - Wiley Online Library
HAJ Al Lawati, ZM Al Dahmani, FEO Suliman, SMZ Al Kindy, AM Al‐Lawati
Luminescence, 2011•Wiley Online Library
ABSTRACT A simple, rapid and sensitive method has been developed for the analysis of
fexofenadine (FEX) in pharmaceutical formulations, using a tris (1, 10‐phenanthroline)–
ruthenium (II)[Ru (phen) 32+] peroxydisulphate chemiluminescence (CL) system in a
multichip device. Various parameters that influence the CL signal intensity were optimized.
These included pH, flow rates and concentration of reagents used. Under optimum
conditions, a linear calibration curve in the range 0.05–5.0 µg/mL was obtained. The …
Abstract
A simple, rapid and sensitive method has been developed for the analysis of fexofenadine (FEX) in pharmaceutical formulations, using a tris(1,10‐phenanthroline)–ruthenium(II) [Ru(phen)32+] peroxydisulphate chemiluminescence (CL) system in a multichip device. Various parameters that influence the CL signal intensity were optimized. These included pH, flow rates and concentration of reagents used. Under optimum conditions, a linear calibration curve in the range 0.05–5.0 µg/mL was obtained. The detection limit was found to be 0.001 µg/mL. The procedure was applied to the analysis of FEX in pharmaceutical products and was found to be free from interference from concomitants usually present in these preparations. Copyright © 2011 John Wiley & Sons, Ltd.
Wiley Online Library
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