CA125 antigen is a mucin-type molecule with a complex protein backbone and
oligosaccharide chain structure. In this study, we characterized CA125 antigen from human
amniotic fluid by gel filtration, ion-exchange chromatography, peptide mass fingerprinting
and lectin-binding assays. The obtained results indicate CA125 to be structurally
heterogeneous, existing in different glycoisoforms with subtle differences in the profile of
molecular forms in comparison to placental tissue-derived and cancer-derived CA125 …