We describe a new methodology for deriving source-specific emission ratios of nitrogen oxides (NO x) to carbon dioxide (CO 2) from space-based TROPOspheric Monitoring Instrument (TROPOMI) and Orbiting Carbon Observatory-2 (OCO-2) observations. The approach is based on scaling the observed ratio along the OCO-2 track with simulated data, in order to obtain the NO x-to-CO 2 emission ratio at the source. We analyze fourteen TROPOMI/OCO-2 collocations from near the Matimba coal-fired power station in South Africa. We obtain a mean NO x-to-CO 2 emission ratio of 2. 6× 10− 3 and standard deviation of 0. 6× 10− 3 (or 23%). When applied to NO x emission estimates derived from TROPOMI data, we obtain annual CO 2 emissions of 62, 60 and 58 kt/d for the years 2018, 2019 and 2020, respectively, with standard deviation of 20 kt/d (or 33%). These values are consistent with existing inventories such as the Open-source Data Inventory for Anthropogenic CO 2 (ODIAC). The proposed method will also work ideally for new and upcoming satellite observations systems such as OCO-3, CO2M and GOSAT-GW.