This article discusses the impact of spiritual and emotional intelligence on the performance of Catholic Religious Education (CRE) teachers in South Papua, with the intervening variable is altruistic professional behavior. Three hypotheses are tested using structural equation modeling. The analysis results show that the three hypotheses proposed are all proved to be significant. The findings indicate that work and achievement are not only due to the financial gain, but there are more important things: the existence of values that are believed. These values are a set of principles that is held firmly by someone to achieve various goals in life and becomes the spirit of dedication. The selflessly dedication can encourage the teachers of CRE to carry out their role as transformers, facilitators, motivators, learning planners, and learning inspiration for their students. Altruistic professional behavior can be practiced as an educational human resource instrument to educate students in this country.