Gastrointestinal nematodes (GIN) impair animal productivity through reduction in voluntary food intake and/or inefficient use of nutrients. Disturbance in protein metabolism and reduced absorption and/or retention of minerals are significant during parasite infection (Waller, 1987). The control of GINs predominantly depends upon chemotherapy despite advancements in genetical, immunological and biotechnological methods (Lloyd-Evans, 1991). Development of drug resistance in the parasites, effect of drug residues on human (Bowman et al., 1999) and high costs of the synthetic drugs, however, have led to attention of the workers to find the alternatives to the existing chemicals used for the treatment and/or control of parasites (Al-Shaibani et al., 2009; Bachaya et al., 2009; Deeba et al., 2009; Sindhu et al., 2010). Plants and/or their products have been used for treatment of different diseases for centuries. Anti-parasitic efficacy of different plants using standard parasitological procedures has been reported earlier (Dolan et al., 2007). In the present study, a combination of the aqueous extracts of leaves of Azadirachta (A.) indica (locally known as Neem) and Nicotiana (N.) tabacum (locally known as Tambaku), flowers of Calotropis (C.) procera (locally known as Aak) and seeds of Trachyspermum (T.) ammi (locally known as Ajwain) have been tested for their anthelmintic activity.