The study was aimed to investigate the anthelmintic efficacy of aqueous seed extract of Carica papaya against gastrointestinal helminths of goats. The animals positive for helminth infestation were selected and given aqueous seed extract of Carica papaya while, normal healthy control group was kept without any treatment. Haemo-biochemical parameters were assessed. Aqueous seed extract of Carica papaya demonstrated significant decrease in average EPG count of helminth infested goats. The progressive per cent decrease in EPG was observed as 41.26%, 73.80% and 90.47% on 3rd day, 7th day and on 21st day post-treatment respectively. Haematological parameters showed appreciable increase however, biochemical parameters were unaffected indicating extract having better efficacy on blood profile. Based on the results obtained in this study it was found that, the aqueous extract of Carica papaya possesses better anthelmintic activity and could offer an alternative source for control of gastrointestinal helminths of goats.