Anthracycline chemotherapy is a widely-used and effective treatment for a wide spectrum of
childhood cancers. Its use is limited by associated progressive and clinically significant
cardiotoxic effects. Onset can be acute, early, or late. While acute onset is rare, long-term
survivors have significantly elevated rates of cardiac morbidity and mortality. Major
complications include cardiomyopathy, coronary artery disease, and atherosclerosis. Means
of prevention and treatment continue to be explored including limiting cumulative …

Anthracycline cardiotoxicity in long‐term survivors of childhood cancer: The light is not at
the end of the tunnel - Hudson - 2007 - Pediatric Blood & Cancer - Wiley Online Library …