Background Several studies have reported that metformin can reduce the risk of
hepatocellular carcinoma (HCC) in diabetes patients. However, the direct anti-HCC effects
of metformin have hardly been studied in patients, but have been extensively investigated in
animal models of HCC. We therefore performed a systematic review and meta-analysis of
animal studies evaluating the effects of metformin on HCC. Methods We collected the
relevant studies by searching EMBASE, Medline (OvidSP), Web of Science, Scopus …

Background Several studies have reported that metformin can reduce the risk of
hepatocellular carcinoma (HCC) in diabetes patients. However, the direct anti-HCC effects
of metformin have hardly been studied in patients, but have been extensively investigated in
animal models of HCC. We therefore performed a systematic review and meta-analysis of
animal studies evaluating the effects of metformin on HCC. Methods We collected the
relevant studies by searching EMBASE, Medline (OvidSP), Web of Science, Scopus …