Antibacterial activity of 5-aminoorotic acid derivatives
M El Kolli, A Coulibaly, J Chevalier, J Barbe… - Current …, 1998 - Springer
M El Kolli, A Coulibaly, J Chevalier, J Barbe, A Cremieux
Current microbiology, 1998•SpringerThe antibacterial activity of several new 5-aminoorotic acid derivatives considered as
possible competitors of orotate towards dihydroorotase has been investigated. Products with
a bromacetamido substitution demonstrated antibacterial properties. However, the
paradoxical behavior of some compounds in synthetic media, opposed to the expected
results obtained with an E. coli strain lacking dehydroorotic dehydrogenase, did not allow us
to draw conclusions on their mechanism of action.
possible competitors of orotate towards dihydroorotase has been investigated. Products with
a bromacetamido substitution demonstrated antibacterial properties. However, the
paradoxical behavior of some compounds in synthetic media, opposed to the expected
results obtained with an E. coli strain lacking dehydroorotic dehydrogenase, did not allow us
to draw conclusions on their mechanism of action.
Abstract
The antibacterial activity of several new 5-aminoorotic acid derivatives considered as possible competitors of orotate towards dihydroorotase has been investigated. Products with a bromacetamido substitution demonstrated antibacterial properties. However, the paradoxical behavior of some compounds in synthetic media, opposed to the expected results obtained with an E. coli strain lacking dehydroorotic dehydrogenase, did not allow us to draw conclusions on their mechanism of action.
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