Antibiotic treatment for Tuberculosis induces a profound dysbiosis of the microbiome that persists long after therapy is completed
MF Wipperman, DW Fitzgerald, MAJ Juste, Y Taur… - Scientific reports, 2017 - nature.com
Mycobacterium tuberculosis, the cause of Tuberculosis (TB), infects one third of the world's
population and causes substantial mortality worldwide. In its shortest format, treatment of TB
requires six months of multidrug therapy with a mixture of broad spectrum and mycobacterial
specific antibiotics, and treatment of multidrug resistant TB is longer. The widespread use of
this regimen makes this one of the largest exposures of humans to antimicrobials, yet the
effects of TB treatment on intestinal microbiome composition and long-term stability are …
population and causes substantial mortality worldwide. In its shortest format, treatment of TB
requires six months of multidrug therapy with a mixture of broad spectrum and mycobacterial
specific antibiotics, and treatment of multidrug resistant TB is longer. The widespread use of
this regimen makes this one of the largest exposures of humans to antimicrobials, yet the
effects of TB treatment on intestinal microbiome composition and long-term stability are …
[引用][C] Antibiotic treatment for tuberculosis induces a profound dysbiosis of the microbiome that persists long after therapy is completed. Sci Rep 7: 10767
MF Wipperman, DW Fitzgerald, MAJ Juste, Y Taur… - 2017
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