Antibodies induced by an ancestral SARS-CoV-2 strain that cross-neutralize variants from Alpha to Omicron BA. 1
Neutralizing antibodies that recognize the SARS-CoV-2 spike glycoprotein are the principal
host defense against viral invasion. Variants of SARS-CoV-2 bear mutations that allow
escape from neutralization by many human antibodies, especially those in widely distributed
(“public”) classes. Identifying antibodies that neutralize these variants of concern and
determining their prevalence are important goals for understanding immune protection. To
determine the Delta and Omicron BA. 1 variant specificity of B cell repertoires established by …
host defense against viral invasion. Variants of SARS-CoV-2 bear mutations that allow
escape from neutralization by many human antibodies, especially those in widely distributed
(“public”) classes. Identifying antibodies that neutralize these variants of concern and
determining their prevalence are important goals for understanding immune protection. To
determine the Delta and Omicron BA. 1 variant specificity of B cell repertoires established by …
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