Anticancer efficiency of doxorubicin and berberine-loaded PCL nanofibers in preventing local breast cancer recurrence
S Mozaffari, S Seyedabadi, E Alemzadeh - Journal of Drug Delivery …, 2022 - Elsevier
The combination of anticancer drugs with plant-derived natural products not only enhances
the cytotoxicity of chemical drugs in cancer cells but also ameliorates their toxicity in normal
cells. In this study, the composite nanofibers of PCL containing anticancer drug doxorubicin
(DOX) and berberine (BBR) were fabricated using the electrospinning method. The cytotoxic
effects of nanofibers were evaluated on MCF-7 breast cancer cells. The drug release profile
was also investigated at different pH (5.4 and 7.4). In addition, the expression levels of BCL …
the cytotoxicity of chemical drugs in cancer cells but also ameliorates their toxicity in normal
cells. In this study, the composite nanofibers of PCL containing anticancer drug doxorubicin
(DOX) and berberine (BBR) were fabricated using the electrospinning method. The cytotoxic
effects of nanofibers were evaluated on MCF-7 breast cancer cells. The drug release profile
was also investigated at different pH (5.4 and 7.4). In addition, the expression levels of BCL …
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