Antihyperglycemic effect of Coscinium fenestratum and Catharanthus roseus in alloxan-induced diabetic rats

S Manoharan, S Umadevi, S Jayanthi… - International Journal of …, 2011 - journals.lww.com
Materials and Methods: Diabetes mellitus was induced in overnight fasted (> 8 hours) Wistar
rats by single intraperitoneal injection of freshly prepared alloxan monohydrate (150 mg/kg
bw) solution in physiological saline. The mechanistic pathway for the antidiabetic potential of
these plants was evaluated by analyzing the status of glucose, insulin, C-peptide,
glycosylated hemoglobin, activities of carbohydrate-metabolizing enzymes, and glycogen
content. The antidiabetic effect of these plant products was also compared with the standard …
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