Ethnopharmacological knowledge has firm traditional and conceptual base built on a tremendous observational data and theoretical structure but lack experimental base, and scientific evidence is needed to prove rationale of using this indigenous flora to preserve and prosper the cultural legacy. Researchers are blending traditional knowledge with experimental methodology for testing efficacy and safety of these herbal remedies. The current study has been designed to authenticate antimalarial, antiemetic and antidiabetic activities of methanolic extracts of Grewia asiatica L. leaves. The extract revealed significant antimalarial, antiemetic and antidiabetic activity. These results indicated the potential of G. asiatica leaves to further explore as natural source for new lead compounds against malaria, diabetes and emesis.