Antisense oligodeoxynucleotides targeted against molecular chaperonin Hsp60 block human hepatitis B virus replication
SG Park, SM Lee, G Jung - Journal of Biological Chemistry, 2003 - ASBMB
The major role of hepatitis B virus polymerase (HBV pol) is polymerization of nucleotides,
but it also participates in protein priming and the packaging of its own genome into capsids.
Therefore, HBV pol may require many assistance factors for its roles. Previous reports have
shown that Hsp60, a molecular chaperone, activates HBV pol both in vitro and ex vivo, such
as inside insect cells. Moreover, HBV pol binds to Hsp60 in the HepG2 host cell line. In this
report, we show that Hsp60 plays a role in the in vivo replication of HBV. Antisense …
but it also participates in protein priming and the packaging of its own genome into capsids.
Therefore, HBV pol may require many assistance factors for its roles. Previous reports have
shown that Hsp60, a molecular chaperone, activates HBV pol both in vitro and ex vivo, such
as inside insect cells. Moreover, HBV pol binds to Hsp60 in the HepG2 host cell line. In this
report, we show that Hsp60 plays a role in the in vivo replication of HBV. Antisense …
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