Therapeutic nucleic acids are powerful molecules for shutting down protein expression.
However, their cellular uptake is poor and requires transport vectors, such as cationic
polymers. Of these, poly (ethylenimine)(PEI) has been shown to be an efficient vehicle for
nucleic acid transport into cells. However, cytotoxicity has been a major hurdle in the
development of PEI–DNA complexes as clinically viable therapeutics. We have synthesized
antisense–polymer conjugates, where the polymeric block is completely monodisperse and …

… Correction: Antisense precision polymer micelles require less poly(ethylenimine) for
efficient gene knockdown … Correction for ‘Antisense precision polymer micelles require
less poly(ethylenimine) for efficient gene knockdown’ by Johans J. Fakhoury, et al.,
Nanoscale, 2015, 7, 20625–20634. …