Oral administration of 50% EtOH-Extract of Solanum xanthocarpum S&W root to male albino rats at dose levels of 50, 100 or 200 mg/kg body weight/rat day^-1 for 60 days resulted in degenerative changes in seminiferous tubules and spermatogenic germinal elements in the testes. Cholesterol, ascorbic acid, fructose, protein and sialic acid content of the testes and sex accessories were significantly decreased. It is suggested that androgen deprivation inhibited spermatogenesis and was reflected in low sperm density, sperm motility and fertility of the treated rats. The possible antispermatogenic activity of S. xanthocarpum root extract is discussed.