Anxiogenic effects during withdrawal from acute ethanol in adolescent and adult rats
TL Doremus, SC Brunell, EI Varlinskaya… - Pharmacology …, 2003 - Elsevier
Elevated signs of anxiety are observed in adult rodents during withdrawal from chronic as
well as acute ethanol exposure. To determine whether adolescents, in addition to their
insensitivity to a number of acute ethanol effects, might likewise be hyposensitive to these
anxiogenic manifestations of withdrawal from an acute ethanol challenge, the behavior of
adolescent and adult male Sprague–Dawley rats was assessed in an elevated plus maze
(EPM) 18 h following intraperitoneal challenge with 4 g/kg ethanol. Adult but not adolescent …
well as acute ethanol exposure. To determine whether adolescents, in addition to their
insensitivity to a number of acute ethanol effects, might likewise be hyposensitive to these
anxiogenic manifestations of withdrawal from an acute ethanol challenge, the behavior of
adolescent and adult male Sprague–Dawley rats was assessed in an elevated plus maze
(EPM) 18 h following intraperitoneal challenge with 4 g/kg ethanol. Adult but not adolescent …
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