[PDF][PDF] Anxiolytic activity of marine macroalgae Sargassum ilicifolium and Padina tetrastomatica in mice
SR Yende, UN Harle, AM Ittadwar - Int. J. Pharm. Pharm. Sci, 2016 - academia.edu
SR Yende, UN Harle, AM Ittadwar
Int. J. Pharm. Pharm. Sci, 2016•academia.eduObjective: The present study was designed to investigate an anxiolytic effect of chloroform
and ethanol extract of Sargassum ilicifolium (SI) and Padina tetrastomatica (PT) in mice.
Methods: Acute toxicity study was done as per OECD 423 guidelines. Based on acute
toxicity studies, doses of 200, 400 and 600 mg/kg of SI and PT extracts were selected, and
the anxiolytic activity was assessed using Elevated plus maze (EPM) and light/dark
exploration (L/DE) tests. Results: Diazepam (2 mg/kg), the ethanol extract of SI (400 mg/kg) …
and ethanol extract of Sargassum ilicifolium (SI) and Padina tetrastomatica (PT) in mice.
Methods: Acute toxicity study was done as per OECD 423 guidelines. Based on acute
toxicity studies, doses of 200, 400 and 600 mg/kg of SI and PT extracts were selected, and
the anxiolytic activity was assessed using Elevated plus maze (EPM) and light/dark
exploration (L/DE) tests. Results: Diazepam (2 mg/kg), the ethanol extract of SI (400 mg/kg) …
Abstract
Objective: The present study was designed to investigate an anxiolytic effect of chloroform and ethanol extract of Sargassum ilicifolium (SI) and Padina tetrastomatica (PT) in mice.
Methods: Acute toxicity study was done as per OECD 423 guidelines. Based on acute toxicity studies, doses of 200, 400 and 600 mg/kg of SI and PT extracts were selected, and the anxiolytic activity was assessed using Elevated plus maze (EPM) and light/dark exploration (L/DE) tests.
Results: Diazepam (2 mg/kg), the ethanol extract of SI (400 mg/kg) as well as ethanol extract of PT (600 mg/kg) significantly increased time spent and entries into the open arm in EPM test. In L/DE test Diazepam, chloroform extract (600 mg/kg) and ethanol extract (400 mg/kg) of SI as well as chloroform extract (600 mg/kg) and ethanol extract (600 mg/kg) of PT significantly increased time spent in light box and transition between the boxes.
Conclusion: in the present investigation, ethanol extract at 400 and chloroform extract at 600 mg/kg of Sargassum ilicifolium as well as ethanol extract at 400 and 600 mg/kg and chloroform extract at 600 mg/kg of Padina tetrastomatica exhibited an anxiolytic effect in the experimental model of anxiety. However, additional research will be necessary to investigate the mechanism underlying this anxiolytic activity.
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