Apolipoprotein AI and high-density lipoprotein have anti-inflammatory effects on adipocytes via cholesterol transporters: ATP-binding cassette A-1, ATP-binding …
T Umemoto, CY Han, P Mitra, MM Averill… - Circulation …, 2013 - Am Heart Assoc
Rationale: Macrophage accumulation in adipose tissue associates with insulin resistance
and increased cardiovascular disease risk. We previously have shown that generation of
reactive oxygen species and monocyte chemotactic factors after exposure of adipocytes to
saturated fatty acids, such as palmitate, occurs via translocation of NADPH oxidase 4 into
lipid rafts (LRs). The anti-inflammatory effects of apolipoprotein AI (apoAI) and high-density
lipoprotein (HDL) on macrophages and endothelial cells seem to occur via cholesterol …
and increased cardiovascular disease risk. We previously have shown that generation of
reactive oxygen species and monocyte chemotactic factors after exposure of adipocytes to
saturated fatty acids, such as palmitate, occurs via translocation of NADPH oxidase 4 into
lipid rafts (LRs). The anti-inflammatory effects of apolipoprotein AI (apoAI) and high-density
lipoprotein (HDL) on macrophages and endothelial cells seem to occur via cholesterol …
[PDF][PDF] Apolipoprotein AI and High-Density Lipoprotein Have Anti-Inflammatory Effects on Adipocytes via Cholesterol Transporters
A ATP-Binding Cassette… - Circulation …, 2013 - academia.edu
Objective: To determine whether apoAI and HDL inhibit inflammation in adipocytes and
adipose tissue, and whether this is dependent on LRs. Methods and Results: In 3T3L-1
adipocytes, apoAI, HDL, and methyl-β-cyclodextrin inhibited chemotactic factor expression.
ApoAI and HDL also disrupted LRs, reduced plasma membrane cholesterol content,
inhibited NADPH oxidase 4 translocation into LRs, and reduced palmitate-induced reactive
oxygen species generation and monocyte chemotactic factor expression. Silencing ATP …
adipose tissue, and whether this is dependent on LRs. Methods and Results: In 3T3L-1
adipocytes, apoAI, HDL, and methyl-β-cyclodextrin inhibited chemotactic factor expression.
ApoAI and HDL also disrupted LRs, reduced plasma membrane cholesterol content,
inhibited NADPH oxidase 4 translocation into LRs, and reduced palmitate-induced reactive
oxygen species generation and monocyte chemotactic factor expression. Silencing ATP …
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