Appendectomy, tonsillectomy and Parkinson's disease risk: a Swedish register-based study
Introduction: The gut-brain hypothesis proposes that Parkinson's disease (PD) pathology
may start in the gut and later spread to the brain in a prion-like manner. As PD pathology is
redundant in the appendix and tonsils, which are important gut-associated lymphoid tissues,
we examined whether appendectomy and tonsillectomy were associated with later PD risk.
Methods: The nested case-control study included 78,650 PD patients born in 1900–1980
and with a diagnosis of PD between 1964 and 2010. For each PD patient, we randomly …
may start in the gut and later spread to the brain in a prion-like manner. As PD pathology is
redundant in the appendix and tonsils, which are important gut-associated lymphoid tissues,
we examined whether appendectomy and tonsillectomy were associated with later PD risk.
Methods: The nested case-control study included 78,650 PD patients born in 1900–1980
and with a diagnosis of PD between 1964 and 2010. For each PD patient, we randomly …
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