In this study, integrated geostatistical techniques were applied to appraise the groundwater quality for various purposes in the Lower Anayari Catchment (LAC), Ghana. Physico-chemical and trace metals were analysed for 41 groundwater samples. Groundwater in LAC was generally found to be moderately hard to fresh and the information entropy-based groundwater quality index (IEGQI) ranked approximately 80.49% of the groundwater as excellent. Partial Least square regression analysis suggests that PO₄³⁻, As, Cd and Fe are important parameters for the prediction of IEGQI values. The irrigation water quality index (IWQI) suggest that 2.44% of groundwater in LAC is suitable for moderate permeability soils, 65.85% for moderate to high permeability soils and 31.71% for moderate to high salt tolerance plants. The LSI and RSI indices rate groundwater in LAC to be aggressive water with a high probability of being corrosive to metals, depending on the levels of dissolved oxygen present.