Arabidopsis casein kinase 2 triggers stem cell exhaustion under Al toxicity and phosphate deficiency through activating the DNA damage response pathway
P Wei, M Demulder, P David, T Eekhout… - The Plant …, 2021 - academic.oup.com
Aluminum (Al) toxicity and inorganic phosphate (Pi) limitation are widespread chronic abiotic
and mutually enhancing stresses that profoundly affect crop yield. Both stresses strongly
inhibit root growth, resulting from a progressive exhaustion of the stem cell niche. Here, we
report on a casein kinase 2 (CK2) inhibitor identified by its capability to maintain a functional
root stem cell niche in Arabidopsis thaliana under Al toxic conditions. CK2 operates through
phosphorylation of the cell cycle checkpoint activator SUPPRESSOR OF GAMMA …
and mutually enhancing stresses that profoundly affect crop yield. Both stresses strongly
inhibit root growth, resulting from a progressive exhaustion of the stem cell niche. Here, we
report on a casein kinase 2 (CK2) inhibitor identified by its capability to maintain a functional
root stem cell niche in Arabidopsis thaliana under Al toxic conditions. CK2 operates through
phosphorylation of the cell cycle checkpoint activator SUPPRESSOR OF GAMMA …
Arabidopsis Casein Kinase 2 triggers Stem Cell Exhaustion under Al Toxicity and Phosphate Deficiency Through activation of the DNA Damage Response pathway
W Pengliang, M Demulder, P David, T Eekhout… - 2020 - europepmc.org
Aluminum (Al) toxicity and inorganic phosphate (Pi) limitation are widespread chronic abiotic
and mutually enhancing stresses that profoundly affect crop yield. Both stresses cause a
strong inhibition of root growth, resulting from a progressive exhaustion of the stem cell
niche. Here, we report on a casein kinase 2 (CK2) inhibitor identified by its capability to
maintain a functional root stem cell niche under Al toxic conditions. CK2 operates through
phosphorylation of the cell cycle checkpoint activator SUPPRESSOR OF GAMMA …
and mutually enhancing stresses that profoundly affect crop yield. Both stresses cause a
strong inhibition of root growth, resulting from a progressive exhaustion of the stem cell
niche. Here, we report on a casein kinase 2 (CK2) inhibitor identified by its capability to
maintain a functional root stem cell niche under Al toxic conditions. CK2 operates through
phosphorylation of the cell cycle checkpoint activator SUPPRESSOR OF GAMMA …
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