Arsenic induces pancreatic β-cell apoptosis via the oxidative stress-regulated mitochondria-dependent and endoplasmic reticulum stress-triggered signaling …
Arsenic (As), a ubiquitous toxic metal, is an important environmental and industrial pollutant
throughout the world. Inorganic As (iAs) is usually more harmful than organic ones and with
a high risk of diabetes incidence by exposure. However, the toxicological effects of iAs on
growth and function of pancreatic β-cells still remain unclear. Here, we found that iAs
significantly decreased insulin secretion and cell viability, and increased ROS and MDA
formation in pancreatic β-cell-derived RIN-m5F cells. iAs also induced the increases in sub …
throughout the world. Inorganic As (iAs) is usually more harmful than organic ones and with
a high risk of diabetes incidence by exposure. However, the toxicological effects of iAs on
growth and function of pancreatic β-cells still remain unclear. Here, we found that iAs
significantly decreased insulin secretion and cell viability, and increased ROS and MDA
formation in pancreatic β-cell-derived RIN-m5F cells. iAs also induced the increases in sub …