Arsenic trioxide and thalidomide combination produces multi-lineage hematological responses in myelodysplastic syndromes patients, particularly in those with high …
A Raza, S Buonamici, L Lisak, S Tahir, D Li, M Imran… - Leukemia research, 2004 - Elsevier
Twenty-eight myelodysplastic syndromes (MDS) patients were treated with arsenic trioxide
(ATO) and thalidomide. Seven patients responded including one complete hematologic and
cytogenetic response and one with regression in spleen size. Two trilineage responses
were seen in patients with inv (3)(q21q26. 2). Three of five patients who had high pre-
therapy EVI1 levels showed unexpectedly good responses while two died early in the first
cycle. In vitro studies using 32Dcl3 cells forced to express EVI1 confirmed increased …
(ATO) and thalidomide. Seven patients responded including one complete hematologic and
cytogenetic response and one with regression in spleen size. Two trilineage responses
were seen in patients with inv (3)(q21q26. 2). Three of five patients who had high pre-
therapy EVI1 levels showed unexpectedly good responses while two died early in the first
cycle. In vitro studies using 32Dcl3 cells forced to express EVI1 confirmed increased …
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