Asiaticoside polymeric nanoparticles for effective diabetic wound healing through increased collagen biosynthesis: In-vitro and in-vivo evaluation
Asiaticoside (AST) is a naturally available phytoconstituent that enables effective wound
healing mainly by promoting collagen biosynthesis. However, the physicochemical nature of
AST such as high molecular weight (959.12 g/mol), poor water solubility and poor
permeability limits its therapeutic effects. This study aims to develop Asiaticoside polymeric
nanoparticles (AST PNP) embedded in a gelatin based biodegradable hydrogel (15% w/v)
for application in the wound cavity to enable sustained release of AST and enhance its …
healing mainly by promoting collagen biosynthesis. However, the physicochemical nature of
AST such as high molecular weight (959.12 g/mol), poor water solubility and poor
permeability limits its therapeutic effects. This study aims to develop Asiaticoside polymeric
nanoparticles (AST PNP) embedded in a gelatin based biodegradable hydrogel (15% w/v)
for application in the wound cavity to enable sustained release of AST and enhance its …
Asiaticoside polymeric nanoparticles for effective diabetic wound healing through increased collagen biosynthesis: In-vitro and in-vivo evaluation
D Chitkara, A Mittal - 2023 - dspace.bits-pilani.ac.in
Asiaticoside (AST) is a naturally available phytoconstituent that enables effective wound
healing mainly by promoting collagen biosynthesis. However, the physicochemical nature of
AST such as high molecular weight (959.12 g/mol), poor water solubility and poor
permeability limits its therapeutic effects. This study aims to develop Asiaticoside polymeric
nanoparticles (AST PNP) embedded in a gelatin based biodegradable hydrogel (15% w/v)
for application in the wound cavity to enable sustained release of AST and enhance its …
healing mainly by promoting collagen biosynthesis. However, the physicochemical nature of
AST such as high molecular weight (959.12 g/mol), poor water solubility and poor
permeability limits its therapeutic effects. This study aims to develop Asiaticoside polymeric
nanoparticles (AST PNP) embedded in a gelatin based biodegradable hydrogel (15% w/v)
for application in the wound cavity to enable sustained release of AST and enhance its …
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