[PDF][PDF] Assessing the therapeutic effect of resveratrol in heart failure following blunt chest trauma and the potential role of endocan as a biomarker of inflammation …
AÇ Torun, Ş Tütüncü - … of Trauma & Emergency Surgery/Ulusal …, 2019 - jag.journalagent.com
AÇ Torun, Ş Tütüncü
Turkish Journal of Trauma & Emergency Surgery/Ulusal Travma ve …, 2019•jag.journalagent.comABSTRACT BACKGROUND: The present study investigated the therapeutic effect of
resveratrol on cardiac injury resulting from blunt chest trauma and the utility of endocan as a
biomarker of the inflammation process using rats. METHODS: The rats were randomly
divided into the following four groups (n= 7 in each group): a control group (no treatment or
trauma); trauma-induced group (trauma group); resveratrol group (resveratrol 0.3 mg/kg
administered via the intraperitoneal [ip] route group); and resveratrol+ trauma group …
resveratrol on cardiac injury resulting from blunt chest trauma and the utility of endocan as a
biomarker of the inflammation process using rats. METHODS: The rats were randomly
divided into the following four groups (n= 7 in each group): a control group (no treatment or
trauma); trauma-induced group (trauma group); resveratrol group (resveratrol 0.3 mg/kg
administered via the intraperitoneal [ip] route group); and resveratrol+ trauma group …
Abstract
BACKGROUND: The present study investigated the therapeutic effect of resveratrol on cardiac injury resulting from blunt chest trauma and the utility of endocan as a biomarker of the inflammation process using rats.
METHODS: The rats were randomly divided into the following four groups (n= 7 in each group): a control group (no treatment or trauma); trauma-induced group (trauma group); resveratrol group (resveratrol 0.3 mg/kg administered via the intraperitoneal [ip] route group); and resveratrol+ trauma group (resveratrol 0.3 mg/kg administered via the ip route 1 hour prior to the induction of trauma).
RESULTS: The immunoreactivity of tumor necrosis factor-α and inducible nitric oxide synthase in the trauma group was increased, whereas the reaction intensity in resveratrol+ trauma group was deceased. The mean endocan values of the differed between the groups (p< 0.001). The mean endocan value in the resveratrol+ trauma group was higher than that of the other groups.
CONCLUSION: Resveratrol exhibited anti-inflammatory and antioxidant effects in lung injury after blunt chest trauma and contributed favorably to the treatment process. We believe that there is a need for further studies on the clinical use of endocan as a biomarker of inflammation in cardiac injury after blunt chest trauma.
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