The aim of this study was to determine if salivary creatinine responds to changes in concentrations in health, disease and treatment, and how these changes relate to changes in blood creatinine levels. Creatinine was assayed in both blood and saliva of 29 haemodialysed subjects; before haemodialyis and after haemodialysis; and 21 healthy individuals who made up the control group. Creatinine was assayed using Jaffe method. The mean±SD concentrations of salivary creatinine in pre and post haemodialysed subjects as well as control group were 143.3±21.3umol/l, 56.6±8.8umo1/1 and 15.7±1.7umol1/1 respectively. The mean±SD concentrations of blood creatinine in pre and post haemodialysed subjects as well as control group were 646.3±29.0umo1/1, 211.1±7.7umo1/1 and 78.5±2.4umo1/1 respectively. The correlation coefficient between blood and salivary creatinine in pre-haemodialysed subjects was -0.12 while that for post haemodialysed subjects was 0.11 and for the control group was 0.02. The salivary creatinine in the three groups (pre, post and control) was statistically significant (F=23.85; P-value <0.05). The blood creatinine in the three groups (pre, post and control) was statistically significant (F=291.98; P-value <0.05). From the various results obtained, salivary creatinine responds to changes in concentration after therapeutic administration. Salivary creatinine may be considered along with other parameters a supportive marker for diagnosis of kidney disease.