Assessment of salivary immunoglobulin A, interleu-kin-6 and C-reactive protein in chronic kidney dis-ease patients on hemodialysis and on conservative treatment
IK Salim, AR Diajil - Journal of Baghdad College of …, 2022 - jbcd.uobaghdad.edu.iq
IK Salim, AR Diajil
Journal of Baghdad College of Dentistry, 2022•jbcd.uobaghdad.edu.iqBackground: Chronic kidney disease is a gradual loss of kidney function with diabetes and
hypertension as the leading cause. Chronic kidney disease is one of these systemic
diseases that can affect salivary contents. Aims: This study aimed to assess salivary
immunoglobulin A, interleukin-6 and C-reactive protein in chronic kidney disease patients
on hemodialysis and those on conservative treatment in comparison with control subjects.
Materials and methods: Ninety subjects were included in this study divided into three …
hypertension as the leading cause. Chronic kidney disease is one of these systemic
diseases that can affect salivary contents. Aims: This study aimed to assess salivary
immunoglobulin A, interleukin-6 and C-reactive protein in chronic kidney disease patients
on hemodialysis and those on conservative treatment in comparison with control subjects.
Materials and methods: Ninety subjects were included in this study divided into three …
Background
Chronic kidney disease is a gradual loss of kidney function with diabetes and hypertension as the leading cause. Chronic kidney disease is one of these systemic diseases that can affect salivary contents.
Aims
This study aimed to assess salivary immunoglobulin A, interleukin-6 and C- reactive protein in chronic kidney disease patients on hemodialysis and those on conservative treatment in comparison with control subjects.
Materials and methods
Ninety subjects were included in this study divided into three groups: 30 patients with chronic kidney disease on hemodialysis for at least 6 months ago; 30 patients with chronic kidney disease on conservative treatment and 30 healthy control subjects. Secretory immunoglobulin A, interleukin-6 and C- reactive protein in saliva samples were measured by enzyme-linked immunosorbent assay ELISA.
Results
No significant difference in salivary immunoglobulin A level among study groups was seen. A significant increase in salivary interleukin-6 and C- reactive protein in both chronic kidney disease patients on hemodialysis and those on conservative treatment compared to the control group. While, no significant salivary IL-6 and CRP differences were seen between both patient groups, on hemodialysis and conservative treatment.
Conclusions
There was no significant difference among chronic kidney disease patients on hemodialysis, on conservative treatment and control healthy subjects regarding to salivary IgA while Salivary interleukin -6 and C- reactive protein was significantly higher in chronic kidney disease patients on hemodialysis and those on conservative treatment compared to healthy subjects.
jbcd.uobaghdad.edu.iq
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