Assessment of the radiation absorbed dose produced by 177Lu-iPSMA, 225Ac-iPSMA and 223RaCl2 to prostate cancer cell nuclei in a bone microenvironment model
E Azorín-Vega, E Rojas-Calderón… - Applied Radiation and …, 2019 - Elsevier
This research aimed to assess the radiation absorbed dose produced by 177 Lu-iPSMA
(177 Lu-prostate specific membrane antigen inhibitor), 225 Ac-iPSMA and 223 RaCl 2 to
prostate cancer cell nuclei in a simplified model of bone by using an experimental in-vitro
prostate cancer LNCaP cell biokinetic study and Monte Carlo simulation with the MCNPX
code. Results showed that 225 Ac-iPSMA releases a nine hundred-fold radiation dose
greater than 177 Lu-iPSMA and 14 times more than 223 RaCl 2 per unit of activity retained …
(177 Lu-prostate specific membrane antigen inhibitor), 225 Ac-iPSMA and 223 RaCl 2 to
prostate cancer cell nuclei in a simplified model of bone by using an experimental in-vitro
prostate cancer LNCaP cell biokinetic study and Monte Carlo simulation with the MCNPX
code. Results showed that 225 Ac-iPSMA releases a nine hundred-fold radiation dose
greater than 177 Lu-iPSMA and 14 times more than 223 RaCl 2 per unit of activity retained …
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