Background: Malaria is an infection caused by protozoan parasites of the genus Plasmodium, and transmitted by the bite of infected Anopheles mosquitoes. Many studies reported an association between malaria and parasitic density with a different ABO blood group, but with contradictory results. Objective: The purpose of this study was to determine the association between ABO blood groups and Malaria parasiticinfection.

Methods: Two hundred and six samples from Sudanese population were included in this study (103 of them were Malaria patients and the other 103 were healthy controls), all of them were evaluated to determine the ABO blood groups. The blood group of the study participants was determined by direct ABO method. Results: in our study there was asignificant association between the ABO blood group and malaria infection with (p value 0.013). The most frequent blood group among patient group was A (42, 40.8%), followed by O (28, 27.2%), B (26, 25.2%), and at last AB (7, 6.8%).

Conclusion: The current study revealed that most frequent blood group in patient group was A, followed by O, B, and eventually AB, the males were more affected by malaria than females and blood group B is more susceptible to the infection by malaria than other blood groups.