Background: Depressive symptoms are a common stroke sequela, yet their neurobiological
substrates are still unclear. We sought to determine if they are associated with specific lesion
locations. Methods: In a prospective observational study, 270 patients with stroke were
tested twice with the Hospital Anxiety and Depression Scale around day 6 and again 6
months poststroke and voxel-based lesion behavior mapping was performed. Results:
Frequency of depressive symptoms (depression subscale of the Hospital Anxiety and …

Background and Purpose: Poststroke depression is a common stroke sequel, yet its
neurobiological substrates are still unclear. We sought to determine whether specific lesion
locations are associated with depressive symptoms after stroke. Methods: In a prospective
study, 270 patients with first ever stroke were repeatedly tested with the depression subscale
of the Hospital Anxiety and Depression Scale within the first 4 weeks and 6 months after
stroke. Voxel-based lesion behavior mapping based on clinical imaging was performed to …