… Together, T2D and aging may have negative effects on bone metabolism. In … risk of fracture
in older adults. Thus, understanding the fracture risk associated with SGLT-2i in older adults …

… of DPP-4 inhibitors, use of SGLT2 inhibitors was not associated with fracture risk (HR 0.97, …
use of canagliflozin was associated with a decreased risk of fractures (HR 0.47, 95% CI 0.25…

… In order to study the association between change in BMI and fracture risk, we stratified
current use of SGLT-2 inhibitors by change in BMI since the index date. The most recent BMI …

… the association between sodium–glucose cotransporter-2 (… fracture risk in patients with
T2DM treated with SGLT2 … that this increased risk was observed only in older patients with pre-…

… ( 3 ) Canagliflozin has been linked to increased bone turnover markers and decreased
hip bone mineral density (BMD) in older patients with type 2 diabetes. ( 7 ) However, this …

… metabolism and their potential mechanisms and discuss their association with fracture risk.
… , lower estimated glomerular filtration rate (eGFR), longer mean exposure, older age, and …

… Association between current use of metformin plus an SGLT-… further investigate the risk of
fracture with use of SGLT-2 inhibitors in older patients who are at particular risk for fractures, as …

… have found no significant associations between SGLT2i and fractures. While several
observational … the association between SGLT2i use and fracture risk in postmenopausal …

… multiple cardiovascular risk factors, created concern. In the present review, we summarize
the data regarding the association between SGLT2 inhibitors and fracture risk in patients with …

… inhibitor use associates with a higher risk of fractures compared with dipeptidyl peptidase-4
(DPP-4) inhibitors, which have no known association with fracture risk. … cohort of older adults, …