Association of telomere length with risk of disease and mortality
CV Schneider, KM Schneider, A Teumer… - JAMA internal …, 2022 - jamanetwork.com
Importance Telomeres protect DNA from damage. Because they shorten with each mitotic
cycle, leukocyte telomere length (LTL) serves as a mitotic clock. Reduced LTL has been
associated with multiple human disorders. Objective To determine the association between
LTL and overall as well as disease-specific mortality and morbidity. Design, Setting, and
Participants This multicenter, community-based cohort study conducted from March 2006 to
December 2010 included longitudinal follow-up (mean [SD], 12 [2] years) for 472 432 …
cycle, leukocyte telomere length (LTL) serves as a mitotic clock. Reduced LTL has been
associated with multiple human disorders. Objective To determine the association between
LTL and overall as well as disease-specific mortality and morbidity. Design, Setting, and
Participants This multicenter, community-based cohort study conducted from March 2006 to
December 2010 included longitudinal follow-up (mean [SD], 12 [2] years) for 472 432 …
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