Atlas of epistasis

C Chatelain, S Lessard, V Thuillier, C Carliez, D Rajpal… - medRxiv, 2021 - medrxiv.org
epistasis and we provide the full summary statistics results to researchers interested in studying
epistasis… We tested for epistasis all variant pairs presenting significant epistasis in a UK …

A high-resolution gene expression atlas of epistasis between gene-specific transcription factors exposes potential mechanisms for genetic interactions

K Sameith, S Amini, MJA Groot Koerkamp… - BMC biology, 2015 - Springer
… The result is a high-resolution atlas of gene expression-based genetic interactions that
provides systems-level insight into GSTF epistasis. The atlas confirms known genetic interactions …

[PDF][PDF] Network medicine-based epistasis detection in complex diseases: ready for quantum computing

M Hoffmann, JM Poschenrieder, M Incudini… - Nucleic Acids …, 2024 - academic.oup.com
… -based epistasis detection via local search), an epistasis … interpretable candidate sets of
epistatic interaction between SNPs (… The Epistasis Disease Atlas can further be queried through …

[HTML][HTML] Identifying epistasis in cancer genomes: a delicate affair

J van de Haar, S Canisius, KY Michael, EE Voest… - Cell, 2019 - cell.com
… as groups of genes in which mutations are epistatic with one another or, specifically, “…
Researchers should view current epistasis maps with caution until we better understand the …

Widespread genetic epistasis among cancer genes

X Wang, AQ Fu, ME McNerney, KP White - Nature communications, 2014 - nature.com
Quantitative genetic epistasis has been hypothesized to be an important factor in the
development and progression of complex diseases. Cancers in particular are driven by the …

The ubiquitous nature of epistasis in determining susceptibility to common human diseases

JH Moore - Human heredity, 2003 - karger.com
epistasis or genegene interaction plays a role in susceptibility to common human diseases.
In this paper, we formulate a working hypothesis that epistasis … First, the idea that epistasis is …

Considerations in the search for epistasis

M Balvert, J Cooper-Knock, J Stamp, RP Byrne… - Genome Biology, 2024 - Springer
… We consider the central combinatorial challenge of epistasis identification through two …
biological observations of epistasis. We start with the idea that search for epistasis should always …

Mitochondrial-nuclear epistasis underlying phenotypic variation in breast cancer pathology

PR Bushel, J Ward, A Burkholder, J Li, B Anchang - Scientific Reports, 2022 - nature.com
epistasis between nuclear genes or mutations in the mitochondrial genome. However,
there is limited understanding about the epistatic … in The Cancer Genome Atlas (TCGA) for …

The genomic physics of COVID-19 pathogenesis and spread

A Dong, J Zhao, C Griffin, R Wu - Cells, 2021 - mdpi.com
epistasis as edges, and high-order cross-genome epistasis as hyperedges in a series of
mobile hypergraphs. Charting a genome-wide atlas of horizontally epistatic … This atlas can …

Graphical analysis of tiller and ear production in a diallel cross of barley

S Jana - Canadian journal of genetics and cytology, 1976 - cdnsciencepub.com
… indicate the presence of duplicate epistasis attributable to the isogenic Atlas lines. As for
tillers, … In the analyses of tiller and ear production per plant, presented in this paper, epistasis, …