Autocatalytic processing of HtrA2/Omi is essential for induction of caspase-dependent cell death through antagonizing XIAP
YM Seong, JY Choi, HJ Park, KJ Kim, SG Ahn… - Journal of Biological …, 2004 - ASBMB
A mature form of nuclear-encoded mitochondrial serine protease HtrA2/Omi is pivotal in
regulating apoptotic cell death; however, the underlying mechanism of the processing event
of HtrA2/Omi and its relevant biological function remain to be clarified. Here, we describe
that HtrA2/Omi is autocatalytically processed to the 36-kDa protein fragment, which is
required for the cytochrome c-dependent caspase activation along with neutralizing XIAP-
mediated inhibition of caspases through interaction with XIAP, eventually promoting …
regulating apoptotic cell death; however, the underlying mechanism of the processing event
of HtrA2/Omi and its relevant biological function remain to be clarified. Here, we describe
that HtrA2/Omi is autocatalytically processed to the 36-kDa protein fragment, which is
required for the cytochrome c-dependent caspase activation along with neutralizing XIAP-
mediated inhibition of caspases through interaction with XIAP, eventually promoting …
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