Human growth hormone (hGH) plays critical roles in pubertal mammary gland growth,
development, and sexual maturation. Accumulated studies have reported that
autocrine/paracrine hGH is an orthotopically expressed oncoprotein that promotes normal
mammary epithelial cell oncogenic transformation. Autocrine/paracrine hGH has also been
reported to promote mammary epithelial cell epithelial-mesenchymal transition (EMT) and
invasion. However, the underlying mechanism remains largely obscure. MicroRNAs …