In this paper, we aim to solve complex real-world image restoration situations, in which, one image may have a variety of unknown degradations. To this end, we propose an all-in-one image restoration framework with latent diffusion (AutoDIR), which can automatically detect and address multiple unknown degradations. Our framework first utilizes a Blind Image Quality Assessment Module (BIQA) to automatically detect and identify the unknown dominant image degradation type of the image. Then, an All-in-One Image Editing (AIR) Module handles multiple kinds of degradation image restoration with the guidance of BIQA. Finally, a Structure Correction Module (SCM) is proposed to recover the image details distorted by AIR. Our comprehensive evaluation demonstrates that AutoDIR outperforms state-of-the-art approaches by achieving superior restoration results while supporting a wider range of tasks. Notably, AutoDIR is also the first method to automatically handle real-scenario images with multiple unknown degradations.