Users, nowadays, are highly educated and trained, therefore, they are eager to solve ordinary problems by themselves without waiting expert’s assistance. To fulfill these needs, the service of knowledge support must be provided in accurate and timely manners. The knowledge service needs to be not only preceded in itself without users’ efforts to search what they want to know, but also delivered pervasively whenever and wherever the users are. Therefore, this paper proposes a framework of autonomous knowledge service, which autonomously provides proper knowledge to users by automatically identifying users’ needs and situations. To provide knowledge services in a pervasive manner, a mobile network technology is additionally applied to the proposed framework. Autonomous as well as pervasive knowledge service can fulfill users’ needs for computing services in the future, and hence underpin the foundation of intelligent, however more human-centered knowledge-based living environments.