Macroautophagy (here autophagy) is a catabolic mechanism responsible for the
degradation of bulk cytoplasm, long-lived proteins and organelles. During autophagy, the
cargos are engulfed by double-membrane structures named phagophores, which expand to
form the autophagosomes. Subsequently, these autophagosomes fuse with lysosomes, in
which the cytoplasmic cargos are degraded. Autophagy is a constitutive process, which
plays an important role in cellular homeostasis. In primary neurons autophagosome …