BIM (BCL-2 interacting mediator of cell death) SAHB (stabilized α helix of BCL2) not always convinces BAX (BCL-2-associated X protein) for apoptosis
The interaction of BAX (BCL-2-associated X protein) with BIM (BCL-2 interacting mediator of
cell death) SAHB (stabilized α helix of BCL2) directly initiates BAX-mediated mitochondrial
apoptosis. This molecular dynamics study reveals that BIM SAHB forms a stable complex
with BAX but it remains in a non-functional conformation. N terminal of BAX folds towards the
core which has been reported exposed in the functional monomer. The α1-α2 loop, which
has been reported in open conformation in functional BAX, acquires a closed conformation …
cell death) SAHB (stabilized α helix of BCL2) directly initiates BAX-mediated mitochondrial
apoptosis. This molecular dynamics study reveals that BIM SAHB forms a stable complex
with BAX but it remains in a non-functional conformation. N terminal of BAX folds towards the
core which has been reported exposed in the functional monomer. The α1-α2 loop, which
has been reported in open conformation in functional BAX, acquires a closed conformation …
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